منابع مشابه
EFFICACY OF FLUMAZENIL IN THE MANAGEMENT OF BENZODIAZEPINE OVERDOSE
Benzodiazepine overdose is the most commonly encountered drug overdose in Iran. It has been reported by many authors that flumazenil possesses highly specific antagonistic activity on central benzodiazepine receptors. We conducted a prospective study on 150 patients brought to the toxicology emergency ward in Loghman-Hakim hospital with benzodiazepine overdose to assess the efficacy of flu...
متن کاملefficacy of flumazenil in the management of benzodiazepine overdose
benzodiazepine overdose is the most commonly encountered drug overdose in iran. it has been reported by many authors that flumazenil possesses highly specific antagonistic activity on central benzodiazepine receptors. we conducted a prospective study on 150 patients brought to the toxicology emergency ward in loghman-hakim hospital with benzodiazepine overdose to assess the efficacy of flumazen...
متن کاملFlumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.
This study evaluates the cardiac and neurologic risks associated with the antagonization of the benzodiazepine component of mixed drug overdoses, when cyclic antidepressants are also implicated. Twenty-four mongrel dogs were anesthetized and ventilated. Electroencephalogram, electrocardiogram, and tidal carbon dioxide and arterial pressure were continuously recorded. Amitriptyline (1 mg/kg/min)...
متن کاملFlumazenil: A specific benzodiazepine antagonist
Flumazenil is a specific benzodiazepine (BZD) antagonist which inhibits the effects of BZD agonists by competing for the receptor site in the central nervous system. It has completed clinical trials in the United States and received final approval from the U.S. Food and Drug Administration for release in January 1992. Following intravenous injection, clinically apparent arousal usually occurs w...
متن کاملTrend of Memory Recovery after Benzodiazepine Overdose
Because of difference in the toxicokinetic and pharmacokinetic characteristics of drugs and with respect to the high rate of benzodiazepine abuse in suicidal attempts, the trend of possible anterograde amnesia after recovery from benzodiazepine overdose were evaluated in Iranian patients. This was a prospective descriptive/analytic clinical trial, which was conducted, in Noor general teaching h...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2016
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.160357